Ozempic and Wegovy have become increasingly popular medications for weight loss, but there are some potential negative side effects to consider before starting on these drugs. Ozempic is an injectable medication that works by decreasing appetite and increasing the feeling of fullness after eating. Ozempic is not FDA-approved for weight management; use for weight loss is off-label. Wegovy and Zepbound are labeled for weight management. It also helps the body use insulin more efficiently, which can help control blood glucose levels in people with type 2 diabetes. Wegovy, available as a once-weekly injection or a once-daily tablet, helps with weight loss by affecting hormones that control hunger and satiety.
While both Ozempic and Wegovy have been shown to be effective in helping people lose weight, they do come with some potential risks. People taking Ozempic have reported nausea, vomiting, diarrhoea, abdominal pain and constipation. The most common side effect associated with Wegovy is nausea, followed by vomiting, diarrhoea and constipation. Low blood sugar can occur, and the risk is higher when these medications are used with insulin or a drug that makes the body release insulin.
In addition to possible side effects of the drug itself, long term use of either medication may pose risks down the road as well. The labels carry a boxed warning: semaglutide causes thyroid C-cell tumors in rodents, and whether it does in humans is unknown. It is contraindicated with a personal or family history of medullary thyroid carcinoma (MTC) or with MEN 2. The labels also warn about pancreatitis (inflammation of the pancreas); stop the drug and seek care if it is suspected. Stop semaglutide at least 2 months before a planned pregnancy, as its labels advise, and talk with your prescriber first. Further research is needed to better understand long-term effects.
Patients comparing medication-based weight loss with surgical options can also read our guide on bariatric surgery vs Ozempic.
Visit Dr. Davtyan in Los Angeles
If you are considering Ozempic, Wegovy, or other medical weight loss options, Dr. David Davtyan provides personalized consultations focused on safety, long-term health goals, and realistic treatment planning. Every evaluation is based on your medical history, weight-loss challenges, and overall health needs.
Davtyan Medical Weight Loss and Wellness helps patients understand potential medication risks, expected outcomes, and when alternative approaches may be appropriate. The goal is to help you make an informed decision with guidance tailored to your individual situation.
