Side Effects of Semaglutide for Weight Loss

Over the years, medical advancements have paved new pathways for individuals struggling with weight management. Among the rising solutions is semaglutide, a medication initially designed to treat type 2 diabetes but now widely used to aid in weight loss. Approved by the FDA for this purpose under the brand name Wegovy, semaglutide has gained attention as a promising tool for obese and overweight individuals. 

Yet, while its results may seem impressive, understanding the side effects of semaglutide is just as important as learning about its benefits. This blog explores what semaglutide does, its side effects, and considerations for those exploring it as a weight loss treatment. 

What Does Semaglutide Do? 

Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA). Its action mimics a naturally occurring hormone (GLP-1) in the body that helps regulate appetite, insulin secretion, and blood sugar levels. For weight loss specifically, it works in the following ways: 

• Appetite Suppression: It modulates appetite by signaling to the brain when you are full, thus reducing calorie intake. 
• Slower Gastric Emptying: It delays the speed at which food leaves the stomach, prolonging feelings of satiety. 
• Improved Blood Sugar Regulation: By enhancing insulin sensitivity and lowering glucose spikes, it minimizes cravings related to blood sugar imbalances. 

While clinical trials show significant weight loss benefits, with participants losing up to 15% of their body weight on average, these effects are achieved alongside a proper diet and exercise regimen. 

However, before deciding to use semaglutide, it is vital to recognize potential side effects and weigh the risks against the benefits. 

Common Side Effects of Semaglutide 

Like any medication, semaglutide may cause side effects, which vary in severity from one individual to another. Below are the most commonly reported side effects based on clinical observations and patient reviews. 

Gastrointestinal Symptoms

Semaglutide impacts the gastrointestinal tract, as its mechanism involves regulating appetite and digestion. 

• Nausea (reported in up to 44% of patients): This is a leading complaint, particularly when starting the treatment or when the dose is increased. 
• Vomiting and Diarrhea (reported in 30% of patients): These symptoms typically appear early but often subside as the body adjusts. 
• Constipation: While less common than nausea, semaglutide may also slow digestion too dramatically, leading to constipation. 

These symptoms are the primary reasons some individuals discontinue the treatment. To minimize their impact, doctors gradually increase dosages and recommend taking the medication with or after meals. 

Fatigue and Headaches 

Some users report fatigue, likely attributed to shifts in diet and caloric intake. Headaches may also occur as the body adjusts to the medication. Patients are advised to stay hydrated and consult with a healthcare provider if the symptoms persist. 

Hypoglycemia 

Though uncommon in non-diabetic individuals, low blood sugar (hypoglycemia) is possible, especially in diabetic patients using semaglutide alongside other glucose-lowering medications like insulin. Hypoglycemia presents symptoms such as dizziness, sweating, and confusion and requires close monitoring. 

Injection Site Reactions 

Since semaglutide is administered as a once-weekly subcutaneous injection, redness, swelling, or irritation at the injection site may occur. Proper administration techniques and rotating injection sites can help minimize this. 

Rare but Serious Side Effects 

Although uncommon, serious side effects have been observed, warranting caution for specific individuals. 

Pancreatitis 

Semaglutide may increase the risk of pancreatitis, an inflammation of the pancreas characterized by severe abdominal pain, nausea, and vomiting. Patients with a history of pancreatitis are often dissuaded from using semaglutide. 

Gallbladder Issues 

Some users report gallbladder issues such as gallstones while on semaglutide. Rapid weight loss—often induced by this medication—may contribute to gallstone formation, as the bile ducts do not adequately process the breakdown of fat reserves. 

Thyroid Tumors 

Animal studies have identified a potential link between semaglutide and thyroid C-cell tumors, although this risk has not been definitively observed in humans. Individuals with a family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 are typically advised against using semaglutide for safety reasons. 

Who Should Avoid Semaglutide? 

While semaglutide represents an exciting development in weight loss medicine, it is not suitable for everyone. Individuals with the following conditions should consult with their physician before proceeding:

• A history of pancreatitis 
• A family history of medullary thyroid cancer 
• Severe gastrointestinal disorders 
• Hypersensitivity to any ingredients in semaglutide 

Pregnant or breastfeeding women should also avoid semaglutide, as its effects on developing fetuses and nursing infants remain inconclusive. 

Should You Choose Semaglutide for Weight Loss? 

Weigh the potential benefits with its risks under the guidance of a trusted healthcare professional. For some, the appeal of clinically-proven weight loss far outweighs minor side effects such as nausea. Others, particularly those with chronic illnesses, may need a tailored approach to weight management. 

At Davtyan Medical Weight Loss and Wellness, we specialize in surgical and medical solutions to help patients achieve their weight loss goals safely and effectively. From lap-band procedures to gastric balloon treatments, we offer comprehensive care to identify the best solution for your needs—whether that includes semaglutide or other alternatives. 

Achieve Weight Loss with Expert Guidance 

Semaglutide offers a compelling option for those struggling with managing their weight, but it’s not a one-size-fits-all solution. Before embarking on this treatment plan, consult with medical professionals who can provide personalized care and insights. 

Contact Davtyan Medical Weight Loss and Wellness today and take the first step toward healthier living.